Investor PresentationTSX: TMD | Nasdaq: TMDI March 18, 2019
A final prospectus containing important information relating to the securities described in this document
has been filed with the securities regulatory authorities in the provinces of British Columbia, Alberta and Ontario. A copy of the final prospectus, and any amendment, is required to be delivered with this document. This document does not
provide full disclosure of all material facts relating to the securities offered. Investors should read the final prospectus and any amendment for disclosure of those facts, especially risk factors relating to the securities offered, before
making an investment decision.The Company has filed a registration statement with the United States Securities and Exchange Commission (the “SEC”) for an offering of units. Before you invest, you should read the prospectus in that registration
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Avenue, Suite 1000, Toronto, Ontario, M5H 3B3, Telephone: (416) 548-7522. Disclaimer
This presentation contains “forward-looking information” and "forward-looking statements" which relate to
future events or future performance and reflect the current expectations and assumptions of management of the Company's future growth, results of operations, performance and business prospects, opportunities, and illustrations and prototypes of
the SPORT Surgical Systems. Wherever possible, words such as "may", "would", "could", "will", "anticipate", "believe", "plan", "expect", "intend", "estimate”, “project”, “predict”, “target”, ”potential”, and similar expressions have been used
to identify these forward-looking statements. These statements reflect management's current beliefs with respect to future events and are based on information currently available to management. Forward-looking statements involve significant
risks, uncertainties and assumptions. Many factors could cause the Company's actual results, performance, achievements or technological development and implementation to be materially different from any future results, performance, achievements
or technological development and implementation that may be expressed or implied by such forward-looking statements, including, without limitation, those listed in the "Risk Factors" section of the Company's Annual Information Form in respect
of the fiscal year ended December 31, 2017 and other information contained in the Company’s public filings (which may be viewed at www.sedar.com). Information contained in this presentation is qualified in its entirety by such public filings.
Should one or more of these risks or uncertainties materialize, or should assumptions underlying the forward looking statements prove incorrect, actual results, performance or achievements may vary materially from those expressed or implied by
the forward-looking statements contained in this presentation. These factors should be considered carefully and prospective investors should not place undue reliance on the forward-looking statements. Although the forward-looking statements
contained in the presentation are based upon what management currently believes to be reasonable assumptions as of the date of this presentation, the Company cannot assure prospective investors that actual results, performance or achievements
will be consistent with these forward-looking statements. This presentation does not constitute an offer to sell any class of securities of the Company in any jurisdiction. There is no assurance as to the whether hospitals will purchase at
assumed prices. The Company does not forecast what portion of the total addressable market it will be able to capture. On slide 6, the Company assumes that the information presented in Intuitive Surgical’s news release is accurate, but has not
independently verified the information. Forward-looking Statements
Titan Medical Overview Designer and developer of the SPORT Surgical System, a versatile single-port
platform that is intended to address a growing multibillion-dollar* market for abdominal surgeries performed using robotic technology. Designed for improved clinical performance, ease of use, operating room efficiency, and hospital economics.
*Robotically Assisted Surgical (RAS) Devices market to grow at 11.7% CAGR for the next 5 years and reach $5.3 billion in 2021, RAS Devices Market Report, Meddevicetracker Group. 4
Novel Clinical Paradigm Multi-articulated triangulation through a single incision Promising Physician
Feedback Tested by international surgeons from 4 surgical disciplines45 preclinical studies 9 peer-reviewed abstract presentations and one published manuscript Robust IP Portfolio 100+ global patents and applications Disruptive Business
Model Projected savings on capital equipment, service and procedure costsCompelling recurring revenue model Commercial Momentum U.S. launch planned in 2020 using direct sales strategy Favorable Market Dynamics Large, underpenetrated
marketApplicable to multiple minimally invasive procedures Investment Highlights
Open surgery offers broad applicationRequires significant hospital stay and recovery timeRisk of adverse
events Evolution of Surgical Care * Press Release: Intuitive Surgical Announces Preliminary Fourth Quarter and Full Year 2018 Results, January 9, 2019 Minimally Invasive Surgery (MIS) has been a growing trend over the past 25 yearsReduced
hospitalization timeReduced risk of adverse eventsRequires highly skilled surgeons Robotic surgery further expands upon the benefits of MISOver 1 million* global robotic procedures were performed in 2018Technology remains expensive with
procedural and operational limitations Application of da Vinci® Single-Site in GYN and general surgery shows early promiseda Vinci SP® single port robotic system received FDA clearance for urology in 2018Robotic visualization, precision and
dexterity with triangulation delivered through a single incision – such as the SPORT System – the next frontier.
Today’s Robotic Surgery Environment Robotic technology was introduced to mitigate the risks of MIS,
reduce variations in procedural efficiency and improve consistency of patient outcomes. Benefits Increased DexterityImproved Visualization (3D)Improved Ergonomics The SPORT Surgical System offers the benefits of multi-articulated surgery
through a single point of entry at a targeted lower cost.
Technology DifferentiationEngineered for Simplicity and Efficiency Single-
IncisionWith a single incision made around the umbilicus, the result can be near-scarless surgery Small FootprintEnhanced mobility and ease-of-use leads to quicker deployment in multiple ORs and higher utilization Multi-ArticulatingSingle-use
end-effectors on reusable multi-articulating instrument arms result in optimal and economical device performance in every procedure Open Display3D high-definition display offers the perfect balance of surgical immersion and situational
awareness in the OR Ergonomic WorkstationHighly ergonomic workstation with natural handle interface enables comfortable surgical posture, even during long procedures PurposefulDesignDesigned from the ground up to improve:Clinical
CapabilitiesOR EfficiencyHospital Economics
System Overview Versatile single-port robotic surgery solutionSmaller OR footprint than multiport
systemsDesigned to overcome multi-port robotic surgery limitationsEngineered for performance, efficiency and cost-effectivenessExpected to provide access to underserved market segments, such as ambulatory surgery centers 9
Workstation Open, unobtrusive 3D high-definition display platform on a 4K monitor Integrated software
for simulation training (in collaboration with Mimic Technologies, Inc.) Ergonomically focused design Easily maneuverable with swiveling easy-gliding coasters Multi-configurable elbow rest and foot pedal positioning Natural
multi-articulated handle interface 10
Patient Cart Easy to load and unload instruments through a detachable camera insertion tube Compact,
rollers enable mobility to maneuver and position Single-arm configuration with no external moving parts facilitates simple setup and assistant-friendly surgery Instruments and 3D high-definition camera delivered through a camera insertion
tube of 25 millimeter diameter Minimal cable management in OR Single-port enables swift multi-quadrant positioning 11
Multi-Articulated Instruments Hunter Style Grasper Dissector Hook Needle Driver Traditional
Grasper Scissors monopolar compatible monopolar compatible bipolar compatible S-Works Section Distal Section translational movement 2 axis multi-articulated movement Tip Section rotation + open/close movement Variety of multi-use
instruments with single patient use end effectors for grasping, suturing, cutting and coagulation bipolar compatible Open architecture for adaptation of future end effectors and functionality
Single-IncisionSurgery + Enhanced Robotic Technology SPORT Surgical System is designed to provide
surgeons with multi-articulated instruments in a triangulated configuration through single-port access to the body. Optimal PatientCare
Areas of the SPORT Surgical System covered by patents or pending
applications: Intellectual PropertyThe SPORT Surgical System is a unique single-incision robotic system that is differentiated by its patented multi-articulating instruments, user interface and ergonomic features.Differentiated and innovative
design provides a strong position on freedom to operate. 30 U.S. & International Patents Issued 77 Applications Pending
Proven Feasibility in Wide Variety of Procedures45 Procedures Performed to Date (live porcine unless
otherwise indicated) GYN and GYN-ONC (8 procedures at Columbia University and Florida Hospital):Radical Hysterectomy with Bilateral Salpingo Oophorectomy and Bilateral Pelvic / Para-Aortic Node DissectionSimple Hysterectomy with Bilateral
Salpingo Oophorectomy and Bilateral Pelvic Node DissectionSimple Hysterectomy with Bilateral Salpingo OophorectomyUrology (19 procedures at IHU Strasbourg and Florida Hospital):Hemi-Nephrectomy and Partial NephrectomyProstatectomy (Human
Cadaver)PyeloplastyUreteral-Bladder AnastomosisGeneral Surgery (14 procedures at IHU Strasbourg and Florida Hospital):Cholecystectomy (1 Human Cadaver, 5 Live Porcine)Nissen Fundoplication (1 Human Cadaver, 3 Live Porcine)Esophagectomy (Human
Cadaver)GastrectomySplenectomyColorectal (4 procedures at Florida Hospital):ColectomyLow Anterior Resection
Multi-disciplinary applications of a new robotic platform by Barbara Seeliger, MD and Lee Swanstrom, MD
(IHU Strasbourg)Accepted and presented at Society of American Gastrointestinal and Endoscopic Surgeons Meeting, Seattle, WA, April 2018 Single-port prostatectomy using SPORT Surgical System by Eric Barret, MD (IMM, France)Accepted and presented
at EAU Section of Urology Technology Meeting, Modena, Italy, May 2018Multispecialty single port robotic technology applied in the live animal model: proof of concept by Travis Rogers, MD, Eduardo Parra Davila, MD, Vipul Patel, MD (all from
Florida Hospital), Ricardo Estape, MD (South Miami GOG) and Armando Melani, MD (IRCAD Brazil) Accepted and presented as a poster at Society of Robotic Surgery Meeting, Stockholm, Sweden, June 2018Feasibility of single-port partial nephrectomy
using SPORT surgical system by Eric Barret, MD (IMM, France)Accepted and presented as a poster at Society of Robotic Surgery Meeting, Stockholm, Sweden, June 2018Single-port robotic partial and hemi nephrectomy using a novel single port robotic
platform by Sebastien Crouzet, MD (University of Lyon, France) and Barbara Seeliger, MD (IHU Strasbourg)Accepted and presented at EAU Robotic Urology Section Meeting, Marseille, France, September 2018Reverse Objective Structured Assessment of
Technical Skills (Reverse-OSATS) as a means of measuring the capability of the Titan Medical SPORT Surgical System on core surgical principles by Chetna Arora, MD, Arnold P. Advincula, MD (both from Columbia University Medical Center) and
William B. Burke, MD (Stony Brook Cancer Center)Accepted and presented at Society of European Robotic Gynecologic Surgeons Meeting, Milan, Italy, September 2018Multispecialty single port robotic technology applied in the live animal model:
proof of concept by Travis Rogers, MD, Eduardo Parra Davila, MD, Vipul Patel, MD (all from Florida Hospital), Ricardo Estape, MD (South Miami GOG) and Armando Melani, MD (IRCAD Brazil) Accepted and presented at World Congress of Endourology
Meeting, Paris, France, September 2018Feasibility of single-port partial nephrectomy using SPORT surgical system by Eric Barret, MD (IMM, France)Accepted and presented at World Congress of Endourology Meeting, Paris, France, September
2018Reverse Objective Structured Assessment of Technical Skills (Reverse-OSATS) as a means of measuring the capability of the Titan Medical SPORT Surgical System on core surgical principles by Chetna Arora, MD, Arnold P. Advincula, MD (both
from Columbia University Medical Center) and William B. Burke, MD (Stony Brook Cancer Center)Accepted and presented at American Association of Gynecologic Laparoscopists Global Congress, Las Vegas, NV, November 2018 SPORT single-port robotic
surgery is feasible & repeatable. Peer-reviewed Abstracts to Date
Published Manuscript Surgical EndoscopyEnabling single-site laparoscopy: the SPORT platform
Barbara Seeliger1 ·
Michele Diana1 · Jelle P. Ruurda2 · Konstantinos M. Konstantinidis3 · Jacques Marescaux1 · Lee L. Swanström1,4 1 IHU-Strasbourg Institute of Image-Guided Surgery, 1, place de l’Hôpital, 67091 Strasbourg Cedex, France 2 Department of
Surgical Oncology, University Medical Center, Utrecht, Utrecht, Netherlands 3 Department of General, Bariatric, Laparoscopic and Robotic Surgery, Athens Medical Center, Athens, Greece 4 Division of GI/MIS, The Oregon Clinic, Portland, OR, USA
Commercial Timeline 2018 2019 2020 Established US & EU Centers of Excellence Proven
Feasibility Integrated Simulation Training Engineering Confidence Build Design Freeze H1 GLP Animal Studies H1 IDE Approval H2 Submit 510(K) Application H2 Submit Technical File for CE
Mark H2 Anticipated Regulatory Clearance Projected Initial Launch
Targeting growing multibillion-dollar global robotic surgery marketHighly versatile, differentiated
advanced single-port platformDesigned for improved clinical performance, ease of use, operating room efficiency and hospital economicsPotential benefits to patients, surgeons and hospitals versus competitive offeringsSystem performance verified
in preclinical studies with data presented at clinical conferencesAttractive capital and recurring revenue streams expectedExperienced management team with record of success Summary
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