Overview PresentationTSX: TMD | Nasdaq: TMDI March 23, 2020
This presentation contains “forward-looking information” and "forward-looking statements" which relate to
future events or future performance and reflect the current expectations and assumptions of management of the Company's future growth, results of operations, performance and business prospects, opportunities, and illustrations and prototypes of
the SPORT Surgical Systems. Wherever possible, words such as "may", "would", "could", "will", "anticipate", "believe", "plan", "expect", "intend", "estimate”, “project”, “predict”, “target”, ”potential”, and similar expressions have been used
to identify these forward-looking statements. These statements reflect management's current beliefs with respect to future events and are based on information currently available to management. Forward-looking statements involve significant
risks, uncertainties and assumptions. Many factors could cause the Company's actual results, performance, achievements or technological development and implementation to be materially different from any future results, performance, achievements
or technological development and implementation that may be expressed or implied by such forward-looking statements, including, without limitation, those listed in the "Risk Factors" section of the Company's Annual Information Form in respect
of the fiscal year ended December 31, 2018, the additional risks set forth in the Company’s management’s discussion and analysis in respect of the three and nine months ended September 30, 2019, and other information contained in the Company’s
public filings (which may be viewed at www.sedar.com and at www.sec.gov). Information contained in this presentation is qualified in its entirety by such public filings. Should one or more of these risks or uncertainties materialize, or should
assumptions underlying the forward-looking statements prove incorrect, actual results, performance or achievements may vary materially from those expressed or implied by the forward-looking statements contained in this presentation. These
factors should be considered carefully and prospective investors should not place undue reliance on the forward-looking statements. Although the forward-looking statements contained in the presentation are based upon what management currently
believes to be reasonable assumptions as of the date of this presentation, there is no assurance that actual results, performance or achievements will be consistent with these forward-looking statements. This presentation does not constitute an
offer to sell any class of securities of the Company in any jurisdiction. There is no assurance as to the whether hospitals will purchase at assumed prices. The Company does not forecast what portion of the total addressable market it will be
able to capture. Forward-looking Statements
Titan Medical Overview Designer and developer of a versatile single-port platform for performing
abdominal surgeries using robotic technology. Designed for improved clinical performance, ease-of-use, operating room efficiency and hospital economics. 3
Novel Clinical Paradigm Multi-articulated instrument triangulation through a single incision Promising
Physician Feedback Tested by U.S. and EU surgeons from 4 surgical disciplines45 preclinical studies prior to 15 GLP studies in 20199 peer-reviewed abstract presentations and 1 published manuscript Robust IP Portfolio 130+ global patents and
applications Disruptive Business Model Projected savings on capital equipment, service and procedure costsRecurring revenue model based on consumable components Pre-commercial Momentum Focused Eastern U.S. launch planned using direct sales
strategy Favorable Market Dynamics Underpenetrated market due to size, complexity and costs associated with existing robotic surgical systemsApplicable to multiple minimally invasive procedures Investment Highlights
Open surgery offers broad applicationRequires significant hospital stay and recovery timeRisk of adverse
events Evolution of Surgical Care Minimally Invasive Surgery (MIS) has been increasing over the past 25 yearsReduced hospitalization timeReduced risk of adverse eventsRequires highly skilled surgeons Robotic surgery further expands upon the
benefits of MISTechnology remains expensive with procedural and operational limitations Application of da Vinci® Single-Site in GYN and general surgery showed early promiseda Vinci SP® single port robotic system received FDA clearance for
urology in 2018, ENT in 2019Titan Medical plans to deliver robotic visualization, precision and dexterity with triangulation through a single incision
Today’s Robotic Surgery Environment Robotic technology was introduced to mitigate the risks of MIS,
reduce variations in procedural efficiency and improve consistency of patient outcomes. Benefits Increased DexterityImproved Visualization (3D)Improved Ergonomics Titan’s single-port robotic system is being developed to offer the benefits of
multi-articulated surgery through a single point of entry in order to reduce trauma.
Technology DifferentiationEngineered for Simplicity and Efficiency Single- IncisionWith a
single incision made around the umbilicus, the result could potentially be near-scarless surgery Small FootprintEnhanced mobility and ease-of-use may lead to quicker deployment in multiple ORs and higher utilization Multi-ArticulatingReusable
multi-articulating instruments are designed for optimal triangulation and economical device performance Open Display3D high-definition display implemented to provide the balance of surgical immersion and situational awareness in the
OR Ergonomic WorkstationHighly ergonomic workstation with natural handle interface designed to enable comfortable surgical posture, even during long procedures PurposefulDesignDesigned from the ground up with the intent of improving:Clinical
CapabilitiesOR EfficiencyHospital Economics
System Overview Versatile single-port robotic surgery solutionSmaller OR footprint than multi-port
systemsDesigned to overcome multi-port robotic surgery limitationsEngineered for performance, efficiency and cost-effectivenessExpected to provide access to underserved market segments, such as ambulatory surgery centers 8
Workstation Open, unobtrusive 3D high-definition display Integrated software for simulation training
(collaboration with Mimic Technologies, Inc.) Ergonomically focused design Easily maneuverable with swiveling easy-gliding coasters Multi-configurable elbow rest and foot pedal positioning Natural multi-articulated handle interface 9
Patient Cart Easy to load and unload instruments through detachable camera insertion tube with
integrated 2D high-definition camera Compact, rollers enable mobility to maneuver and position Single-arm configuration with no external moving parts facilitates simple setup and assistant-friendly surgery Instruments and steerable 3D
high-definition camera delivered through camera insertion tube of 25 mm diameter Minimal cable management in OR Single-port enables swift multi-quadrant positioning 10
Multi-Articulated Instruments Hunter Style Grasper Dissector Hook Needle Driver Traditional
Grasper Scissors monopolar compatible monopolar compatible bipolar compatible S-Works Section Distal Section translational movement 2 axis multi-articulated movement Tip Section rotation + open/close movement Variety of multi-use
instruments and end effectors for grasping, suturing, cutting and coagulation bipolar compatible Open architecture for adaptation of future end effectors and functionality
Single-port surgery with enhanced robotic technology Titan Medical’s single-port surgical system is
designed to provide surgeons with multi-articulated instruments in a triangulated configuration through a single incision. Optimal PatientCare
Areas of Titan Medical’s single-port robotic surgical system covered by
patents or pending applications: Intellectual PropertyA unique single-port robotic surgery system that is differentiated by its patented multi-articulating instruments, user interface and ergonomic features.Differentiated and innovative design
provides a strong position on freedom to operate. 49 U.S. & International Patents Issued 86 Applications Pending
Proven Feasibility in a Wide Variety of Procedures45 Procedures Performed to Date (live porcine unless
otherwise indicated, excludes GLP) GYN and GYN-ONC (8 procedures at Columbia University and Florida Hospital):Radical Hysterectomy with Bilateral Salpingo Oophorectomy and Bilateral Pelvic / Para-Aortic Node DissectionSimple Hysterectomy with
Bilateral Salpingo Oophorectomy and Bilateral Pelvic Node DissectionSimple Hysterectomy with Bilateral Salpingo OophorectomyUrology (19 procedures at IHU Strasbourg and Florida Hospital):Hemi-Nephrectomy and Partial NephrectomyProstatectomy
(Human Cadaver)PyeloplastyUreteral-Bladder AnastomosisGeneral Surgery (14 procedures at IHU Strasbourg and Florida Hospital):Cholecystectomy (1 Human Cadaver, 5 Live Porcine)Nissen Fundoplication (1 Human Cadaver, 3 Live Porcine)Esophagectomy
(Human Cadaver)GastrectomySplenectomyColorectal (4 procedures at Florida Hospital):ColectomyLow Anterior Resection
Multi-disciplinary applications of a new robotic platform by Barbara Seeliger, MD and Lee Swanstrom, MD
(IHU Strasbourg)Accepted and presented at Society of American Gastrointestinal and Endoscopic Surgeons Meeting, Seattle, WA, April 2018 Single-port prostatectomy using SPORT Surgical System by Eric Barret, MD (IMM, France)Accepted and presented
at EAU Section of Urology Technology Meeting, Modena, Italy, May 2018Multispecialty single port robotic technology applied in the live animal model: proof of concept by Travis Rogers, MD, Eduardo Parra Davila, MD, Vipul Patel, MD (all from
Florida Hospital), Ricardo Estape, MD (South Miami GOG) and Armando Melani, MD (IRCAD Brazil) Accepted and presented as a poster at Society of Robotic Surgery Meeting, Stockholm, Sweden, June 2018Feasibility of single-port partial nephrectomy
using SPORT surgical system by Eric Barret, MD (IMM, France)Accepted and presented as a poster at Society of Robotic Surgery Meeting, Stockholm, Sweden, June 2018Single-port robotic partial and hemi nephrectomy using a novel single port robotic
platform by Sebastien Crouzet, MD (University of Lyon, France) and Barbara Seeliger, MD (IHU Strasbourg)Accepted and presented at EAU Robotic Urology Section Meeting, Marseille, France, September 2018Reverse Objective Structured Assessment of
Technical Skills (Reverse-OSATS) as a means of measuring the capability of the Titan Medical SPORT Surgical System on core surgical principles by Chetna Arora, MD, Arnold P. Advincula, MD (both from Columbia University Medical Center) and
William B. Burke, MD (Stony Brook Cancer Center)Accepted and presented at Society of European Robotic Gynecologic Surgeons Meeting, Milan, Italy, September 2018Multispecialty single port robotic technology applied in the live animal model:
proof of concept by Travis Rogers, MD, Eduardo Parra Davila, MD, Vipul Patel, MD (all from Florida Hospital), Ricardo Estape, MD (South Miami GOG) and Armando Melani, MD (IRCAD Brazil) Accepted and presented at World Congress of Endourology
Meeting, Paris, France, September 2018Feasibility of single-port partial nephrectomy using SPORT surgical system by Eric Barret, MD (IMM, France)Accepted and presented at World Congress of Endourology Meeting, Paris, France, September
2018Reverse Objective Structured Assessment of Technical Skills (Reverse-OSATS) as a means of measuring the capability of the Titan Medical SPORT Surgical System on core surgical principles by Chetna Arora, MD, Arnold P. Advincula, MD (both
from Columbia University Medical Center) and William B. Burke, MD (Stony Brook Cancer Center)Accepted and presented at American Association of Gynecologic Laparoscopists Global Congress, Las Vegas, NV, November 2018 Single-port robotic surgery
with Titan’s system is feasible & repeatable. Peer-reviewed Abstracts to Date
Published Manuscript Surgical EndoscopyEnabling single-site laparoscopy: the SPORT platform
Barbara Seeliger1 ·
Michele Diana1 · Jelle P. Ruurda2 · Konstantinos M. Konstantinidis3 · Jacques Marescaux1 · Lee L. Swanström1,4 1 IHU-Strasbourg Institute of Image-Guided Surgery, 1, place de l’Hôpital, 67091 Strasbourg Cedex, France 2 Department of
Surgical Oncology, University Medical Center, Utrecht, Utrecht, Netherlands 3 Department of General, Bariatric, Laparoscopic and Robotic Surgery, Athens Medical Center, Athens, Greece 4 Division of GI/MIS, The Oregon Clinic, Portland, OR, USA
Initial U.S. Target: Benign Gynecologic Surgery Rationale:Potential to reduce trauma and scarring, and
offers possibility of faster recovery for an engaged patient populationAbility to produce positive patient outcomes in relatively low-risk benign proceduresViable alternative to other single-port approaches based on gynecologic surgeon feedback
from preclinical studiesAttractive procedure volumes performed in outpatient as well as inpatient settings, favoring smaller footprint and lower-cost modelClarity of regulatory pathwayWith an initial U.S. focus, an ability to efficiently
provide comprehensive product training and support to facilitate early product adoption and consistent, successful outcomes
Highly versatile, differentiated advanced single-port robotic platformDesigned for improved clinical
performance, ease of use, operating room efficiency and hospital economicsPotential benefits to patients, surgeons and hospitals versus competitive offeringsSystem performance verified in preclinical studies with data presented at clinical
conferencesExperienced management team with a record of success Summary
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